Frequency of the mdr-1 C>T gene polymorphism in patients with COPD
Clinics
;
65(11): 1115-1117, 2010. tab
Article
in English
| LILACS
| ID: lil-571426
ABSTRACT
BACKGROUND AND AIM:
The multi-drug resistant-1 (MDR-1) gene is located on human chromosome 7 and encodes a glycosylated membrane protein that is a member of the ATP-binding cassette transporters superfamily. The aim of the study was to reveal the role of the C3435T MDR-1 gene polymorphism in chronic obstructive pulmonary disease.METHOD:
DNA samples from 41 patients with chronic obstructive pulmonary disease and 50 healthy control participants were used to compare MDR-1 gene profiles. Genotyping assays were performed using the StripAssay technique that is based on reverse-hybridization.RESULTS:
The T allele polymorphism in the MDR-1 gene located at position 3435 in exon 26 was shown to correlate with chronic obstructive pulmonary disease.CONCLUSION:
These preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with chronic obstructive pulmonary disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Drug Resistance, Multiple
/
Genes, MDR
/
Pulmonary Disease, Chronic Obstructive
Type of study:
Observational study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS