Maternal MTHFR polymorphisms and risk of spontaneous abortion / Polimorfismos maternos MTHFR y riesgo de aborto espontáneo
Salud pública Méx
;
51(1): 19-25, ene.-feb. 2009. tab
Article
in English
| LILACS
| ID: lil-572701
ABSTRACT
OBJECTIVE:
To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C>T and 1298 A>C). MATERIAL ANDMETHODS:
We conducted a nested case-control study within a perinatal cohort of women recruited in the state of Morelos, Mexico. Twenty-three women with SA were compared to 74 women whose pregnancy survived beyond week 20th. Intake of folate and B vitamins respectively, was estimated using a validated food frequency questionnaire. Maternal MTHFR polymorphisms were determined by PCR-RFLP and serum homocysteine levels by HPLC.RESULTS:
Carriers of MTHFR 677TT and 1298AC genotypes respectively showed an increased risk of SA (OR 677TT vs. CC/CT=5.0; 95 percent CI 1.2, 20.9 and OR 1298 AC vs. AA=5.5; 95 percent CI 1.1, 26.6).CONCLUSIONS:
Our results support the role of MTHFR polymorphisms as a risk factor for SA, regardless of dietary intake of B vitamins.RESUMEN
OBJETIVO:
Evaluar la asociación entre aborto espontáneo (AE) y el consumo dietético de vitaminas B en mujeres mexicanas portadoras de los polimorfismos de la metilentetrahidrofolato reductasa (MTHFR) (677 C>T y 1298 A>C). MATERIAL YMÉTODOS:
Mediante un diseño de casos y controles anidados en una cohorte, se comparó la ingesta dietética materna de vitaminas B y folato, los polimorfismos maternos de la MTHFR y la concentración sérica de homocisteina de 23 casos de AE (< 20 semanas) y 74 controles (mujeres con embarazos > 20 semanas).RESULTADOS:
Las portadoras de los genotipos MTHFR 677TT y 1298AC presentaron un incremento significativo en el riesgo de AE (RM 677TT vs. CC/CT=5.0; IC 95 por ciento 1.2, 20.9 RM 1298 AC vs. AA=5.5; IC95 por ciento 1.1, 26.6), respectivamente.CONCLUSIONES:
Nuestros resultados apoyan el papel de la mutación de la MTHFR como posible factor de riesgo para el AE, independientemente del consumo de vitaminas B.
Full text:
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Index:
LILACS (Americas)
Main subject:
Abortion, Spontaneous
/
Polymorphism, Single Nucleotide
Type of study:
Controlled clinical trial
/
Etiology study
/
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Country/Region as subject:
Mexico
Language:
English
Journal:
Salud pública Méx
Journal subject:
Public Health
Year:
2009
Type:
Article
Affiliation country:
Mexico
/
United States
Institution/Affiliation country:
Mexican Institute of Genomic Medicine/MX
/
Mount Sinai School of Medicine/US
/
National Institute of Public Health/MX
/
Universidad Autónoma del Estado de Querétaro/MX
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