Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats
J. appl. oral sci
;
18(6): 635-640, Nov.-Dec. 2010. ilus, tab
Article
in English
| LILACS
| ID: lil-573736
ABSTRACT
OBJECTIVE:
The aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats. MATERIAL ANDMETHODS:
In 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05).RESULTS:
In the histometric analysis, at 7, 15 and 30 days, Group T (0.72±0.05 mm², 0.57±0.14 mm², 0.62±0.07 mm²), showed less bone loss (p<0.05) than Group C (1.35±0.25 mm²; 1.40±0.31 mm²; 1.29±0.27 mm²), respectively.CONCLUSIONS:
Subgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats.
Full text:
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Index:
LILACS (Americas)
Main subject:
Periodontitis
/
Tetracycline
/
Anti-Bacterial Agents
Type of study:
Evaluation studies
Limits:
Animals
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2010
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
São Paulo State Universit/BR
/
University Center of Educational Foundation of Barretos/BR
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