Pesquisa de hipotiroidismo congénito: resultados de dieciocho años de trabajo ininterrumpido en el Hospital Italiano de Buenos Aires / Survey of congenital hypothyroidism: results of eighteen years of uninterrupted work in the Hospital Italiano de Buenos Aires
Rev. Hosp. Ital. B. Aires (2004)
;
28(2): 57-62, dic. 2008. graf, tab
Article
in Spanish
| LILACS
| ID: lil-575085
RESUMEN
Presentamos la experiencia de la pesquisa de hipotiroidismo congénito (HC) en la que se evaluaron 37.750 neonatos nacidos en el Hospital Italiano de Buenos Aires y su filial de San Justo entre los años 1989 y 2007. Se midió tirotrofina por radioinmunoensayo. Se detectaron 25 neonatos con HC 10 definitivos, 2 transitorios y 13 no confirmados aún; como resultado se registró una prevalencia de HC definitivo de 1/3 775. La causa más frecuente de HC definitivo fue la disgenesia tiroidea. El permanente ajuste de los valores de corte de TSH hizo posible disminuir el porcentaje de falsos positivos y consecuentemente el porcentaje de recitación en un 91.3% en este período. Enfatizamos la importancia de la detección temprana del HC a fin de instaurar un tratamiento precoz y evitar así el retardo mental y neurológico que esta enfermedad produce.
ABSTRACT
To assess the occurrence of congenital hypothyroidism (CH), 37 750 newborns were evaluated at Hospital Italiano deBuenos Aires and its affiliated hospital in San Justo between 1989 and 2007. Determination of thyrotropin by radioimmunoassay allowed for the detection of 25 newborns with CH of whom 10 were definitive, 2 transient and 13 without confirmation at the current time. The prevalence of definitive CH was 1/3775 newborns, being thyroid dysgenesis the most common cause of the disease. A continuous adjustment of TSH threshold values resulted in a decrease of false positive cases with a consequent reduction of 91.3% on office visits for follow-up during this period.We remark on the importance of an early detection of CH so that treatment can be initiated to prevent mental and neurological retardation associated with the disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Receptors, Thyrotropin
/
Thyrotropin
/
Congenital Hypothyroidism
/
Early Diagnosis
/
Thyroid Dysgenesis
/
Hypothyroidism
Type of study:
Diagnostic study
/
Risk factors
/
Screening study
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Spanish
Journal:
Rev. Hosp. Ital. B. Aires (2004)
Journal subject:
Medicine
Year:
2008
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Hospital Italiano de Buenos Aires/AR
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