Carbapenem stewardship: positive impact on hospital ecology
Braz. j. infect. dis
;
15(1): 1-5, Jan.-Feb. 2011. tab
Article
in English
| LILACS
| ID: lil-576777
ABSTRACT
INTRODUCTION:
Excessive group 2 carbapenem use may result in decreased bacterial susceptibility.OBJECTIVE:
We evaluated the impact of a carbapenem stewardship program, restricting imipenem and meropenem use.METHODS:
Ertapenem was mandated for ESBL-producing Enterobacteriaceae infections in the absence of non-fermenting Gram-negative bacilli (GNB) from April 2006 to March 2008. Group 2 carbapenems were restricted for use against GNB infections susceptible only to carbapenems and suspected GNB infections in unstable patients. Cumulative susceptibility tests were done for nosocomial pathogens before and after restriction using Clinical and Laboratory Standards Institute (CLSI) guide-lines.Vitek System or conventional identification methods were performed and susceptibility testing done by disk diffusion according to CLSI.Antibiotic consumption (t-test) and susceptibilities (McNemar's test) were determined.RESULTS:
The defined daily doses (DDD) of group 2 carbapenems declined from 61.1 to 48.7 DDD/1,000 patient-days two years after ertapenem introduction (p = 0.027). Mean ertapenem consumption after restriction was 31.5 DDD/1,000 patient-days. Following ertapenem introduction no significant susceptibility changes were noticed among Gram-positive cocci. The most prevalent GNB were P. aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp. There was no change in P. aeruginosa susceptibility to carbapenems. Significantly improved P. aeruginosa and K. pneumoniae ciprofloxacin susceptibilities were observed, perhaps due to decreased group 2 carbapenem use. K. pneumoniae susceptibility to trimethoprim-sulfamethoxazole improved.CONCLUSION:
Preferential use of ertapenem resulted in reduced group 2 carbapenem use, with a positive impact on P. aeruginosa and K. pneumoniae susceptibility.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pseudomonas aeruginosa
/
Acinetobacter
/
Carbapenems
/
Cross Infection
/
Enterobacteriaceae
/
Anti-Bacterial Agents
Type of study:
Practice guideline
Limits:
Humans
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
USP/BR
/
Universidade de São Paulo/BR
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