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The effects of nitric oxide on the immune response during giardiasis
Pavanelli, Wander Rogério; Gutierrez, Fredy Roberto Salazar; Silva, Jean Jerley Nogueira da; Costa, Ivete Conchon; Menezes, Maria Claudia Noronha Dutra de; Oliveira, Francisco José de Abreu; Itano, Eiko Nakagawa; Watanabe, Maria Angélica Ehara.
  • Pavanelli, Wander Rogério; State University of Londrina. Department of Pathology Science. Londrina. BR
  • Gutierrez, Fredy Roberto Salazar; Universidad Antonio Nariño.
  • Silva, Jean Jerley Nogueira da; University of São Paulo. Institute of Physic of São Carlos. BR
  • Costa, Ivete Conchon; State University of Londrina. Department of Pathology Science. Londrina. BR
  • Menezes, Maria Claudia Noronha Dutra de; State University of Londrina. Department of Pathology Science. Londrina. BR
  • Oliveira, Francisco José de Abreu; State University of Londrina. Department of Pathology Science. Londrina. BR
  • Itano, Eiko Nakagawa; State University of Londrina. Department of Pathology Science. Londrina. BR
  • Watanabe, Maria Angélica Ehara; State University of Londrina. Department of Pathology Science. Londrina. BR
Braz. j. infect. dis ; 14(6): 606-612, Nov.-Dec. 2010.
Article in English | LILACS | ID: lil-578437
ABSTRACT
Nitric oxide (NO) is a free radical synthesized from L-arginine by different isoforms NO-synthases. NO possesses multiple and complex biological functions. NO is an important mediator of homeostasis, and changes in its generation or actions can contribute or not to pathological states. The knowledge of effects of NO has been not only important to our understanding of immune response, but also to new tools for research and treatment of various diseases. Knowing the importance of NO as inflammatory mediator in diverse infectious diseases, we decided to develop a revision that shows the participation/effect of this mediator in immune response induced against Giardia spp. Several studies already demonstrated the participation of NO with microbicidal and microbiostatic activity in giardiasis. On the other hand, some works report that Giardia spp. inhibit NO production by consuming the intermediate metabolite arginine. In fact, studies in vitro showed that G. lamblia infection of human intestinal epithelial cells had reduced NO production. This occurs due to limited offer of the crucial substrate arginine (essential aminoacid for NO production), consequently reducing NO production. Therefore, the balance between giardial arginine consumption and epithelial NO production could contribute to the variability of the duration and severity of infections by this ubiquitous parasite.
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Full text: Available Index: LILACS (Americas) Main subject: Giardiasis / Giardia lamblia / Intestinal Mucosa / Nitric Oxide Limits: Animals / Humans Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2010 Type: Article / Project document Affiliation country: Brazil / Colombia Institution/Affiliation country: State University of Londrina/BR / University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Giardiasis / Giardia lamblia / Intestinal Mucosa / Nitric Oxide Limits: Animals / Humans Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2010 Type: Article / Project document Affiliation country: Brazil / Colombia Institution/Affiliation country: State University of Londrina/BR / University of São Paulo/BR