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ATZ (3-amino-1,2,4-triazole) injected into the fourth cerebral ventricle influences the Bezold-Jarisch reflex in conscious rats
Valenti, Vitor E; Abreu, Luiz Carlos de; Sato, Monica A; Ferreira, Celso.
  • Valenti, Vitor E; Universidade Federal de São Paulo. Departamento de Medicina, Disciplina de Cardiologia. São Paulo. BR
  • Abreu, Luiz Carlos de; Faculdade de Medicina do ABC. Departamento de Morfologia e Fisiologia. Santo André. BR
  • Sato, Monica A; Faculdade de Medicina do ABC. Departamento de Morfologia e Fisiologia. Santo André. BR
  • Ferreira, Celso; Universidade Federal de São Paulo. Departamento de Medicina, Disciplina de Cardiologia. São Paulo. BR
Clinics ; 65(12): 1339-1343, 2010. ilus, graf, tab
Article in English | LILACS | ID: lil-578574
ABSTRACT

OBJECTIVES:

Many studies have investigated the importance of oxidative stress on the cardiovascular system. In this study we evaluated the effects of central catalase inhibition on cardiopulmonary reflex in conscious Wistar rats.

METHODS:

Male Wistar rats were implanted with a stainless steel guide cannula in the fourth cerebral ventricle. The femoral artery and vein were cannulated for mean arterial pressure and heart rate measurement and for drug infusion, respectively. After basal mean arterial pressure and heart rate recordings, the cardiopulmonary reflex was tested with a dose of phenylbiguanide (PBG, 8 μg/kg, bolus). Cardiopulmonary reflex was evaluated before and μl15 minutes after 1.0 μl 3-amino-1,2,4-triazole (ATZ, 0.01g/100μl)0.01 g/100 μl) injection into the fourth cerebral ventricle. Vehicle treatment did not change cardiopulmonary reflex responses.

RESULTS:

Central ATZ significantly increased hypotensive responses without influencing the bradycardic reflex.

CONCLUSION:

ATZ injected into the fourth cerebral ventricle increases sympathetic inhibition but does not change the parasympathetic component of the cardiopulmonary reflex in conscious Wistar rats.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Baroreflex / Consciousness / Fourth Ventricle / Enzyme Inhibitors / Amitrole Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina do ABC/BR / Universidade Federal de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Baroreflex / Consciousness / Fourth Ventricle / Enzyme Inhibitors / Amitrole Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina do ABC/BR / Universidade Federal de São Paulo/BR