High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters
Mem. Inst. Oswaldo Cruz
;
106(1): 51-55, Feb. 2011. tab
Article
in English
| LILACS
| ID: lil-578816
ABSTRACT
Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection.
Full text:
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Index:
LILACS (Americas)
Main subject:
Staphylococcus
/
Catheterization, Central Venous
/
Catheters, Indwelling
/
Biofilms
/
Vancomycin Resistance
/
Anti-Bacterial Agents
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2011
Type:
Article
Affiliation country:
Brazil
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