Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D
Braz. arch. biol. technol
;
54(2): 315-320, Mar.-Apr. 2011. ilus, tab
Article
in English
| LILACS
| ID: lil-582380
ABSTRACT
The aim of this study was to prepare and evaluate the pellets, containing a highly soluble drug (ascorbic acid), by the extrusion-spheronization process and coated with a release controlling polymer. The coating (undertaken in a fluid bed) was applied to three batches of the pellets with a dispersion of Kollicoat® SR 30 D, with each batch of pellets receiving a different level of polymer (5.07; 8.26 and 10.35 percent). The coated pellets were evaluated for sphericity by imaging analysis and comparative dissolution profile with a product commercially available in Brazil. All of the evaluated samples presented adequate physical properties and the dissolution profile of those coated with 5.07 percent of polymer proved to be similar to that of the commercially available brand name.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Braz. arch. biol. technol
Journal subject:
Biology
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Paraná/BR
/
Universidade de São Paulo/BR
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