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Biocompatibility of four root canal sealers: a histopathological evaluation in rat subcutaneous connective tissue
Silveira, Camila Maggi Maia; Pinto, Shelon Cristina Souza; Zedebski, Rosário de Arruda Moura; Santos, Fábio André; Pilatti, Gibson Luiz.
  • Silveira, Camila Maggi Maia; Ponta Grossa State University. Department of Dentistry. Ponta Grossa. BR
  • Pinto, Shelon Cristina Souza; Ponta Grossa State University. Department of Dentistry. Ponta Grossa. BR
  • Zedebski, Rosário de Arruda Moura; Ponta Grossa State University. Department of Dentistry. Ponta Grossa. BR
  • Santos, Fábio André; Ponta Grossa State University. Department of Dentistry. Ponta Grossa. BR
  • Pilatti, Gibson Luiz; Ponta Grossa State University. Department of Dentistry. Ponta Grossa. BR
Braz. dent. j ; 22(1): 21-27, 2011. ilus
Article in English | LILACS | ID: lil-582396
ABSTRACT
The aim of this study was to evaluate the subcutaneous biocompatibility of Epiphany, AH Plus, Pulp Canal Sealer and Sealapex root canal sealers. Sixty rats were randomly assigned to 4 groups, according to the sealer. Polyethylene tubes containing the tested materials were inserted into the connective tissue. The implants were removed after 7, 15 and 30 days, and the tissue samples were processed, stained and examined by light microscopy. The descriptive analysis considered thickness of the fibrous capsule, severity of the inflammatory reaction, and presence of giant cells. After 7 days, all sealers induced moderate to severe inflammatory reaction. After 15 days, Epiphany and AH Plus sealers showed a moderate inflammatory reaction, while Pulp Canal Sealer and Sealapex induced severe and mild inflammatory reactions, respectively. After 30 days, mild inflammatory reactions were observed for Epiphany, Sealapex and AH Plus. Sealapex induced the lowest inflammatory response at all evaluation periods, and only Pulp Canal Sealer did not show a decreased in the inflammatory reaction over time.
RESUMO
O objetivo deste estudo foi avaliar a biocompatibilidade subcutânea de cimentos endodônticos radiculares Epiphany, AH Plus, Pulp Canal Sealer e Sealapex. Sessenta ratos foram divididos aleatoriamente em 4 grupos, de acordo com o cimento. Tubos de polietileno contendo os materiais testados foram inseridos no tecido conjuntivo. Os implantes foram removidos após 7, 15 e 30 dias, e as amostras de tecido foram processadas, coradas e examinadas por microscopia de luz. A análise descritiva considerou espessura da cápsula fibrosa, severidade da reação inflamatória e presença de células gigantes. Após 7 dias, todos os cimentos induziram moderada e severa reação inflamatória. Após 15 dias, os cimentos Epiphany e AH Plus apresentaram uma reação inflamatória moderada, enquanto Pulp Canal Sealer e Sealapex induziram severa e leve reações inflamatórias, respectivamente. Após 30 dias, leve reação inflamatória foi observada para o Epiphany, Sealapex e AH Plus. Sealapex induziu a menor resposta inflamatória em todos os períodos de avaliação, e somente Pulp Canal Sealer não apresentou uma diminuição da reação inflamatória ao longo do tempo.
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Full text: Available Index: LILACS (Americas) Main subject: Root Canal Filling Materials / Subcutaneous Tissue / Inflammation Limits: Animals Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Ponta Grossa State University/BR

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Full text: Available Index: LILACS (Americas) Main subject: Root Canal Filling Materials / Subcutaneous Tissue / Inflammation Limits: Animals Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Ponta Grossa State University/BR