Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents
Biol. Res
;
43(4): 459-465, 2010. ilus
Article
in English
| LILACS
| ID: lil-582861
ABSTRACT
This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53 percent), ethanol/HCl (75 percent), ibuprofen (52 percent) and ischemia/reperfusion (43 percent). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective activity of the extract.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stomach Ulcer
/
Plant Extracts
/
Bromeliaceae
/
Anti-Ulcer Agents
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2010
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Center for Research on Medicinal Plants/BR
/
University of San Francisco Valley/BR
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