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Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica / Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure
WINTER, JOSÉ LUIS; CASTRO, PABLO; MENESES, LUIS; CHALHUB, MÓNICA; VERDEJO, HUGO; GREIG, DOUGLAS; GABRIELLI, LUIGI; CHIONG, MARIO; CONCEPCIÓN, ROBERTO; MELLADO, ROSEMERIE; HERNÁNDEZ, CLAUDIA; URIBE, SERGIO; LAVANDERO, SERGIO.
  • WINTER, JOSÉ LUIS; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Enfermedades Cardiovasculares. CL
  • CASTRO, PABLO; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Enfermedades Cardiovasculares. CL
  • MENESES, LUIS; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Radiología. CL
  • CHALHUB, MÓNICA; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Enfermedades Cardiovasculares. CL
  • VERDEJO, HUGO; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Enfermedades Cardiovasculares. CL
  • GREIG, DOUGLAS; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Enfermedades Cardiovasculares. CL
  • GABRIELLI, LUIGI; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Enfermedades Cardiovasculares. CL
  • CHIONG, MARIO; Universidad de Chile. Centro FONDAP. CL
  • CONCEPCIÓN, ROBERTO; Hospital DIPRECA. Santiago. CL
  • MELLADO, ROSEMERIE; Pontificia Universidad Católica de Chile. Facultad de Ciencias Químicas y Farmacéuticas. CL
  • HERNÁNDEZ, CLAUDIA; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Enfermedades Cardiovasculares. CL
  • URIBE, SERGIO; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Enfermedades Cardiovasculares. CL
  • LAVANDERO, SERGIO; Universidad de Chile. Centro FONDAP. CL
Rev. méd. Chile ; 138(12): 1475-1479, dic. 2010. ilus, tab
Article in Spanish | LILACS | ID: lil-583042
ABSTRACT

Background:

Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (creatine phosphate/ creatine transporter). Magnetic resonance (MR) imaging allows a direct and noninvasive assessment of myocardial metabolites.

Aim:

To measure myocardial creatine and lipids by MR spectroscopy among patients with HF. Material and

Methods:

Cardiac MR spectroscopy (1.5 Tesla) with Hydrogen antenna and single voxel acquisition was performed in fve patients with non-ischemic heart failure, aged 58 ± 9.7 years, (60 percent males) and 5 healthy volunteers matched for age and sex. We analyzed the signals of creatine (Cr), lipids (L) and water (W) in the interventricular septum, establishing the water/lipid (W/L) and water/creatine (W/Cr) index to normalize the values obtained.

Results:

Among patients, left ventricular ejection fraction was 32 ± 6.9 percent, 60 percent were in functional capacity II, 60 percent had hypertension and one was diabetic. Spectroscopic curves showed a depletion of total Cr, evidenced by the W/ Cr index, among patients with heart failure, when compared with healthy controls (1.46 ± 1.21 and 5.96 ± 2.25 respectively, p < 0,05). Differences in myocardial lipid content, measured as the W/L index, were not significant (5.06 ± 2.66 and 1.80 ± 1.62 respectively, p = 0.08).

Conclusions:

Among patients with heart failure of non-ischemic etiology, there is a depletion of creatine levels measured by MR spectroscopy.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Magnetic Resonance Spectroscopy / Creatine / Heart Failure / Lipids / Myocardium Type of study: Observational study / Risk factors Limits: Female / Humans / Male Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2010 Type: Article / Project document Affiliation country: Chile Institution/Affiliation country: Hospital DIPRECA/CL / Pontificia Universidad Católica de Chile/CL / Universidad de Chile/CL

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Full text: Available Index: LILACS (Americas) Main subject: Magnetic Resonance Spectroscopy / Creatine / Heart Failure / Lipids / Myocardium Type of study: Observational study / Risk factors Limits: Female / Humans / Male Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2010 Type: Article / Project document Affiliation country: Chile Institution/Affiliation country: Hospital DIPRECA/CL / Pontificia Universidad Católica de Chile/CL / Universidad de Chile/CL