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Imipramine for vestibular dysfunction in panic disorder: a prospective case series / Imipramina para disfunção vestibular em transtorno do pânico: uma série de casos prospectiva
Mezzasalma, Marco Andre; Mathias, Kátia de Vasconcellos; Nascimento, Isabella; Valença, Alexandre M; Nardi, Antonio E.
  • Mezzasalma, Marco Andre; Federal University of Rio de Janeiro. Psychiatric Institute. Panic and Respiration Laboratory. Rio de Janeiro. BR
  • Mathias, Kátia de Vasconcellos; Federal University of Rio de Janeiro. Psychiatric Institute. Panic and Respiration Laboratory. Rio de Janeiro. BR
  • Nascimento, Isabella; Federal University of Rio de Janeiro. Psychiatric Institute. Panic and Respiration Laboratory. Rio de Janeiro. BR
  • Valença, Alexandre M; Federal Fluminense University. Niterói. BR
  • Nardi, Antonio E; Federal University of Rio de Janeiro. Psychiatric Institute. Panic and Respiration Laboratory. Rio de Janeiro. BR
Arq. neuropsiquiatr ; 69(2a): 196-201, Apr. 2011. ilus, tab
Article in English | LILACS | ID: lil-583795
ABSTRACT

OBJECTIVE:

The purpose of this study was to evaluate the efficacy and effectiveness of imipramine on the treatment of comorbid chronic dizziness and panic disorder.

METHOD:

Nine patients with panic disorder and agoraphobia associated with chronic dizziness underwent otoneurological screening and were treated with a 3-months course of imipramine. Anxiety levels were measured with the Hamilton Anxiety Scale (HAM-A), dizziness levels were evaluated using the Dizziness Handicap Inventory (DHI), and panic severity and treatment outcome were assessed with the Clinical Global Impression Scale (CGI).

RESULTS:

At the baseline 33.3 percent (n=3) had a bilateral peripheral deficit vestibulopathy, the mean scores for HAM-A were 27.2±10.4, for DHI were 51.7±22.7, and for CGI-S were 4.8±0.9. All patients had a significant reduction in their HAM-A (11.1±5.5, p=0.008), DHI (11.5±8.1, p=0.008) and CGI-I (1.8±0.7, p=0.011) levels after 3-months imipramine treatment (mean=72.2±23.2 mg/day).

CONCLUSION:

This study found a decrease in anxiety levels and in the impact of dizziness in the patients' quality of life after a 3-months treatment course with imipramine.
RESUMO

OBJETIVO:

O objetivo deste estudo foi avaliar a eficácia e efetividade da imipramina no tratamento da tontura crônica e do transtorno de pânico comórbidos.

MÉTODO:

Nove pacientes com transtorno do pânico e agorafobia associada com tontura crônica foram submetidos à avaliação otoneurológica e tratados durante 3 meses com imipramina. Os níveis de ansiedade foram medidos através da Escala Hamilton de Ansiedade (HAM-A); os de tontura foram avaliados usando o Dizziness Handicap Inventory (DHI), e a gravidade do pânico e sua resposta pela Escala de Impressão Clínica Global (CGI).

RESULTADOS:

Na avaliação inicial, 33,3 por cento (n=3) da amostra apresentavam vestibulopatia periférica deficitária bilateral; as médias foram da HAM-A 27,2±10,4, do DHI 51,7±22,7 e do CGI-S 4,8±0,9. Todos tiveram uma redução significativa nos escores de HAM-A (11,1±5,5, p=0,008), DHI (11,5±8,1, p=0,008) e CGI-I (1,8±0,7, p=0,011), após 3 meses de tratamento com imipramina (média=72,2±23,2 mg/dia).

CONCLUSÃO:

Este estudo encontrou uma diminuição dos níveis de ansiedade e do impacto da tontura na qualidade de vida dos pacientes após um curso de 3 meses de tratamento com imipramina.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Panic Disorder / Dizziness / Imipramine / Antidepressive Agents, Tricyclic Type of study: Observational study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal Fluminense University/BR / Federal University of Rio de Janeiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Panic Disorder / Dizziness / Imipramine / Antidepressive Agents, Tricyclic Type of study: Observational study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal Fluminense University/BR / Federal University of Rio de Janeiro/BR