Parvovirus B19 antibodies and correlates of infection in pregnant women attending an antenatal clinic in central Nigeria
Mem. Inst. Oswaldo Cruz
;
106(2): 227-231, Mar. 2011. tab
Article
in English
| LILACS
| ID: lil-583950
ABSTRACT
Human parvovirus B19 infection is associated with spontaneous abortion, hydrops foetalis, intrauterine foetal death, erythema infectiosum (5th disease), aplastic crisis and acute symmetric polyarthropathy. However, data concerning Nigerian patients with B19 infection have not been published yet. The purpose of this study was to establish the prevalence of B19 IgG and IgM antibodies, including correlates of infection, among pregnant women attending an antenatal clinic in Nigeria. Subsequent to clearance from an ethical committee, blood samples were collected between August-November 2008 from 273 pregnant women between the ages of 15-40 years who have given their informed consent and completed self-administered questionnaires. Recombinant IgG and IgM enzyme linked immunosorbent assay kits (Demeditec Diagnostics, Germany) were used for the assays. Out of the 273 participants, 111 (40.7 percent) had either IgG or IgM antibodies. Out of these, 75 (27.5 percent) had IgG antibodies whereas 36 (13.2 percent) had IgM antibodies, and those aged 36-40 years had the highest prevalence of IgG antibodies. Significant determinants of infection (p < 0.05) included the receipt of a blood transfusion, occupation and the presence of a large number of children in the household. Our findings have important implications for transfusion and foeto-maternal health policy in Nigeria. Routine screening for B19 IgM antibodies and accompanying clinical management of positive cases should be made mandatory for all Nigerian blood donors and women of childbearing age.
Full text:
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Index:
LILACS (Americas)
Main subject:
Pregnancy Complications, Infectious
/
Immunoglobulin G
/
Immunoglobulin M
/
Parvoviridae Infections
/
Antibodies, Viral
Type of study:
Etiology study
/
Prevalence study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Africa
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2011
Type:
Article
Affiliation country:
Nigeria
Institution/Affiliation country:
Nasarawa State Hospitals Management Board/NG
/
Nasarawa State University/NG
/
National Blood Transfusion Center/NG
/
University of Jos/NG
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