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Evaluation of the antiamnesic effects of Phyllanthus amarus in mice / Evaluación de los efectos antiamnésicos de Phyllanthus amarus en ratones
Joshi, Hanumanthachar; Parle, Milind.
  • Joshi, Hanumanthachar; Soniya Education Trust's College of Pharmacy. Department of Pharmacognosy and Phytomedicine. Dharwad. IN
  • Parle, Milind; Guru Jambheshwar University. Department of Pharmaceutical Sciences. Hisar. IN
Colomb. med ; 38(2): 132-139, abr.-jun. 2007. graf
Article in English | LILACS | ID: lil-586351
ABSTRACT
Alzheimer’s disease is a progressive neurodegenerative disorder characterized by a gradual decline in memory. Phyllanhus amarus is commonly known as bhumi amla in India and is traditionally used since centuries in ayurveda medicine. The present study was undertaken to investigate the effects of Phyllanhus amarus (PA) on cognitive functions and brain cholinesterase activity in mice. Elevated plus maze and passive avoidance paradigm were employed to evaluate learning and memory parameters. Three doses (50, 100 and 200 mg/kg, p.o.) of aqueous extract of PA were administered for 8 successive days to both young and aged mice. PA (50, 100 and 200 mg/kg) produced a dose-dependent improvement in memory scores of young and older mice. PA also reversed successfully the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Interestingly, brain acetyl cholinesterase activity was also reduced. The underlying mechanism of action for the observed nootropic effect may be attributed to pro-cholinergic activity exhibited by PA in the present study. Therefore, it would be worthwhile to explore the therapeutic potential of PA in the management of patients with cognitive disorders.
RESUMEN
La enfermedad de Alzheimer es un desorden neuro-degenerativo progresivo que se caracteriza por una disminución gradual de la memoria. El Phyllanhus amarus (PA), se conoce comúnmente como bhumi amla en la India, y tradicionalmente se ha usado durante siglos en la medicina ayurvédica con diversas indicaciones. Este estudio se hizo para investigar los efectos del PA en las funciones cognitivas y en la actividad de la colinesterasa cerebral. Se emplearon las pruebas de laberinto complejo y el paradigma de evitación pasiva a fin de evaluar los parámetros de memoria y aprendizaje. Se administraron tres dosis (50, 100 y 200 mg/kg vía oral) de extracto acuoso de PA durante 8 días sucesivos, tanto a ratones jóvenes como adultos. El PA (50, 100 y 200 mg/kg) produjo una mejoría que depende de la dosis en los puntajes de memoria en los ratones jóvenes y en los adultos. EL PA también revirtió con éxito la amnesia inducida por escopolamina (0.4 mg/kg, i.p.) y diazepam (1 mg/kg, i.p.). Es de interés anotar que asimismo disminuyó la actividad de la acetil colinesterasa cerebral. El mecanismo de acción subyacente para el efecto nootrópico observado se puede atribuir a la actividad pro-colinesterasa demostrada en el presente estudio. Por tanto, se justificaría explorar el potencial terapéutico del PA en el manejo de pacientes con desórdenes cognitivos.
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Full text: Available Index: LILACS (Americas) Main subject: Scopolamine / Phyllanthus / Alzheimer Disease / Amnesia / Memory / Mice Limits: Animals Language: English Journal: Colomb. med Journal subject: Medicine Year: 2007 Type: Article Affiliation country: India Institution/Affiliation country: Guru Jambheshwar University/IN / Soniya Education Trust's College of Pharmacy/IN

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Full text: Available Index: LILACS (Americas) Main subject: Scopolamine / Phyllanthus / Alzheimer Disease / Amnesia / Memory / Mice Limits: Animals Language: English Journal: Colomb. med Journal subject: Medicine Year: 2007 Type: Article Affiliation country: India Institution/Affiliation country: Guru Jambheshwar University/IN / Soniya Education Trust's College of Pharmacy/IN