Chromosomal and molecular abnormalities in a group of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia attending an infertility service
Int. braz. j. urol
; 37(2): 244-251, Mar.-Apr. 2011. tab
Article
in En
| LILACS
| ID: lil-588997
Responsible library:
BR1.1
ABSTRACT
PURPOSE:
To determine the frequency of genetic alterations in a population of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia. MATERIALS ANDMETHODS:
Retrospective study of a group of 143 infertile men with severe oligozoospermia or non-obstructive azoospermia from the Andrology Outpatient Clinic of the Human Reproduction Service at the ABC School of Medicine. Of these patients, 100 had severe oligozoospermia, and 43 non-obstructive azoospermia. All patients underwent a genetic study which included karyotype analysis and Y-microdeletion investigation.RESULTS:
Genetic abnormalities were found in 18.8 percent of the studied patients. Chromosomal abnormalities were found in 6.2 percent of the patients, being more prevalent in the azoospermia group (11.6 percent) than in the oligozoospermia group (4 percent). Chromosomal variants were found in 8.3 percent, and Y-chromosome microdeletions in 4.2 percent of patients.CONCLUSION:
The high frequency of genetic alterations (18.8 percent) in our series justified performing a genetic investigation in a population with idiopathic infertility, as results may help determine the prognosis, as well as the choice of an assisted reproduction technique. Moreover, a genetic investigation could minimize the risk of transmitting genetic abnormalities to future generations such as genetic male infertility, mental retardation, genital ambiguity and/or birth defects.Key words
Full text:
1
Index:
LILACS
Main subject:
Oligospermia
/
Chromosome Aberrations
/
Chromosome Deletion
/
Chromosomes, Human, Y
/
Azoospermia
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Int. braz. j. urol
Journal subject:
UROLOGIA
Year:
2011
Type:
Article