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Regulatory elements involved in the post-transcriptional control of stage-specific gene expression in Trypanosoma cruzi: a review
Araújo, Patricia R; Teixeira, Santuza M.
  • Araújo, Patricia R; Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte. BR
  • Teixeira, Santuza M; Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte. BR
Mem. Inst. Oswaldo Cruz ; 106(3): 257-266, May 2011. ilus
Article in English | LILACS | ID: lil-589032
ABSTRACT
Trypanosoma cruzi, a protozoan parasite that causes Chagas disease, exhibits unique mechanisms for gene expression such as constitutive polycistronic transcription of protein-coding genes, RNA editing and trans-splicing. In the absence of mechanism controlling transcription initiation, organized subsets of T. cruzi genes must be post-transcriptionally co-regulated in response to extracellular signals. The mechanisms that regulate stage-specific gene expression in this parasite have become much clearer through sequencing its whole genome as well as performing various proteomic and microarray analyses, which have demonstrated that at least half of the T. cruzi genes are differentially regulated during its life cycle. In this review, we attempt to highlight the recent advances in characterising cis and trans-acting elements in the T. cruzi genome that are involved in its post-transcriptional regulatory machinery.
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Full text: Available Index: LILACS (Americas) Main subject: Transcription, Genetic / Trypanosoma cruzi / RNA, Messenger / RNA Processing, Post-Transcriptional / Gene Expression Regulation, Developmental Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR

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Full text: Available Index: LILACS (Americas) Main subject: Transcription, Genetic / Trypanosoma cruzi / RNA, Messenger / RNA Processing, Post-Transcriptional / Gene Expression Regulation, Developmental Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR