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Infection of the lymphatic system by Aureobasidium pullulans in a patient with erythema nodosum leprosum
Morais, Orlando Oliveira de; Porto, Cláudia; Coutinho, Anglya Samara Silva Leite; Reis, Carmélia Matos Santiago; Teixeira, Marcus de Melo; Gomes, Ciro Martins.
Affiliation
  • Morais, Orlando Oliveira de; Universidade de Brasília. University Hospital of Brasilia. Dermatology Residency Program. Brasília. BR
  • Porto, Cláudia; UnB. University Hospital of Brasilia. Department of Dermatology. Brasília. BR
  • Coutinho, Anglya Samara Silva Leite; Universidade de Brasília. University Hospital of Brasilia. Dermatology Residency Program. Brasília. BR
  • Reis, Carmélia Matos Santiago; UnB. University Hospital of Brasilia. Laboratory of Mycology. Brasília. BR
  • Teixeira, Marcus de Melo; UnB. Laboratory of Molecular Biology. Brasília. BR
  • Gomes, Ciro Martins; Universidade de Brasília. University Hospital of Brasilia. Dermatology Residency Program. Brasília. BR
Braz. j. infect. dis ; 15(3): 288-292, May-June 2011. ilus
Article in En | LILACS | ID: lil-589964
Responsible library: BR1.1
ABSTRACT
Aureobasidium pullulans is a causal agent of phaeohyphomycosis, occasionally found in men and animals. As an agent of different opportunistic fungal processes, it may cause fungemia, systemic infections and abscesses in different viscera. This paper aims to report a case of a patient with infection of the lymphatic system by A. pullulans. A 23-year-old patient being treated for erythema nodosum leprosum presented a 60-day complaint of daily fever, hoarseness, odynophagia and weight loss. Laboratory tests showed pancytopenia with severe neutropenia, cervical adenomegaly and solid contrast uptake lesion in the oropharyngeal region. Due to neutropenia and sepsis the patient was initially treated with cefepime and vancomycin, but there was no clinical improvement. Lymph node puncture-aspiration showed yeast-form fungus identified as A. pullulans by sequencing ITS region. The patient was treated with amphotericin B deoxycholate, leading to complete recovery of bone marrow function and regression of adenomegaly and the oropharyngeal lesion.
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Full text: 1 Index: LILACS Main subject: Ascomycota / Leprosy, Lepromatous / Erythema Nodosum / Lymphatic Diseases / Mycoses Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: Braz. j. infect. dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2011 Type: Article

Full text: 1 Index: LILACS Main subject: Ascomycota / Leprosy, Lepromatous / Erythema Nodosum / Lymphatic Diseases / Mycoses Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: Braz. j. infect. dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2011 Type: Article