Trends in adjuvant development for vaccines: DAMPs and PAMPs as potential new adjuvants
Braz. j. med. biol. res
;
44(6): 500-513, June 2011. ilus, tab
Article
in English
| LILACS, SES-SP
| ID: lil-589971
ABSTRACT
Aluminum salts have been widely used in vaccine formulations and, after their introduction more than 80 years ago, only few vaccine formulations using new adjuvants were developed in the last two decades. Recent advances in the understanding of how innate mechanisms influence the adaptive immunity opened up the possibility for the development of new adjuvants in a more rational design. The purpose of this review is to discuss the recent advances in this field regarding the attempts to determine the molecular basis and the general mechanisms underlying the development of new adjuvants, with particular emphasis on the activation of receptors of innate immune recognition. One can anticipate that the use of these novel adjuvants will also provide a window of opportunities for the development of new vaccines.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vaccines
/
Virulence Factors
/
Receptors, Pattern Recognition
/
Adaptive Immunity
/
Immunity, Innate
Limits:
Animals
/
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Butantan/BR
Similar
MEDLINE
...
LILACS
LIS