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Celiac disease screening in patients with scleroderma / Triagem para doença celíaca em pacientes com esclerodermia
Nisihara, Renato; Utiyama, Shirley Rosa; Azevedo, Pedro Ming; Skare, Thelma Larocca.
  • Nisihara, Renato; Hospital de Clínicas. Immunopathology Laboratory.
  • Utiyama, Shirley Rosa; Hospital de Clínicas. Immunopathology Laboratory.
  • Azevedo, Pedro Ming; Rheumatology Unit Hospital Evangélico. Curitiba. BR
  • Skare, Thelma Larocca; Rheumatology Unit Hospital Evangélico. Curitiba. BR
Arq. gastroenterol ; 48(2): 163-164, Apr.-June 2011. ilus
Article in English | LILACS | ID: lil-591168
ABSTRACT
Both celiac disease and scleroderma have autoimmune etiology and affect the bowel causing diarrhea. As an association of autoimmune disease in a single individual is not rare, it is important to know if a patient with scleroderma may also have celiac disease. To analyze this we studied 105 scleroderma patients and 97 volunteers for IgA-EmA by indirect immunofluorescence assay. We could not find a higher prevalence of this autoantibody in scleroderma patients. The authors conclude that there is no need to screen scleroderma patients with diarrhea for celiac disease unless there is a clear clinical indication for this.
RESUMO
Tanto a esclerodermia como a doença celíaca são doenças de autoimunidade que causam diarreia. Como o agrupamento de doenças autoimunes em único indivíduo não é raro, é importante saber se um individuo com esclerodermia tem maiores chances de ter ou não doença celíaca. Para isso, estudaram-se 105 pacientes com esclerodermia e 97 controles saudáveis para o anticorpo EmA IgA. Não foi possível detectar presença aumentada de EmA IgA em pacientes com esclerodermia. Conclui-se que não existe necessidade de busca ativa de doença celíaca em pacientes com esclerodermia e diarreia, a menos que existam evidências clínicas claras da doença.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Scleroderma, Systemic / Autoantibodies / Immunoglobulin A / Celiac Disease / Transglutaminases Type of study: Diagnostic study / Observational study / Risk factors / Screening study Limits: Adult / Female / Humans / Male Language: English Journal: Arq. gastroenterol Journal subject: Gastroenterology Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Rheumatology Unit Hospital Evangélico/BR

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Full text: Available Index: LILACS (Americas) Main subject: Scleroderma, Systemic / Autoantibodies / Immunoglobulin A / Celiac Disease / Transglutaminases Type of study: Diagnostic study / Observational study / Risk factors / Screening study Limits: Adult / Female / Humans / Male Language: English Journal: Arq. gastroenterol Journal subject: Gastroenterology Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Rheumatology Unit Hospital Evangélico/BR