Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
Mem. Inst. Oswaldo Cruz
;
106(4): 507-509, June 2011. graf
Article
in English
| LILACS
| ID: lil-592197
ABSTRACT
In the current study, we evaluated the mechanism of action of miltefosine, which is the first effective and safe oral treatment for visceral leishmaniasis, in Leishmania amazonensis promastigotes. Miltefosine induced a process of programmed cell death, which was determined by the externalization of phosphatidylserine, the incorporation of propidium iodide, cell-cycle arrest at the sub-G0/G1 phase and DNA fragmentation into oligonucleosome-sized fragments. Despite the intrinsic variation that is detected in Leishmania spp, our results indicate that miltefosine causes apoptosis-like death in L. amazonensis promastigote cells using a similar process that is observed in Leishmania donovani.
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Index:
LILACS (Americas)
Main subject:
Phosphorylcholine
/
Leishmania mexicana
/
DNA, Protozoan
/
Apoptosis
/
DNA Fragmentation
/
Antiprotozoal Agents
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fiocruz/BR
/
Universidade Federal do Rio de Janeiro/BR
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