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Therapeutic Effects of Allium sativum and Allium cepa in Schistosoma mansoni experimental infection / Efeitos terapêuticos do Allium sativum e Allium cepa na infecção experimental pelo Schistosoma mansoni
Mantawy, Mona Mohamed; Ali, Hanan Farouk; Rizk, Maha Zaki.
  • Mantawy, Mona Mohamed; s.af
  • Ali, Hanan Farouk; s.af
  • Rizk, Maha Zaki; s.af
Rev. Inst. Med. Trop. Säo Paulo ; 53(3): 155-163, May-June 2011. ilus, graf, tab
Article in English | LILACS | ID: lil-592776
ABSTRACT
The effects of both garlic (Allium sativum) and onion (Allium cepa) on some biochemical parameters in Schistosoma mansoni infected mice individually and mixed either with or without the currently used drug, praziquantel (PZQ) were investigated. These involved some immunological parameters, namely IgM, IgG, interleukins 2 and 6 (IL-2 and 6) and tumor necrosis factor (TNF-α), some antioxidant enzymes [catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPX)]. In addition, parasitological and histopathological investigations were performed. No changes were observed in the normal control mice treated with dry extract of onion or garlic, individually or mixed, with or without PZQ, compared to the normal healthy control group. Infection with S. mansoni showed an increase in IgG, IgM, IL-2, IL-6, TNF-α and catalase enzyme, accompanied with a decrease in GPX and SOD antioxidant enzyme activities. Remarkable amelioration was noticed in the levels of all the measured parameters in S. mansoni infected mice after administration of the studied extracts. Moreover a significant reduction in worm burden, hepatic and intestinal eggs and oogram count was noticed which was reflected in normalization of liver architecture.
RESUMO
Os efeitos do alho (Allium sativum) e cebola (Allium cepa) em parâmetros bioquímicos de camundongos infectados pelo Schistosoma mansoni individualmente e misturados seja com ou sem as drogas correntemente usadas como o Praziquantel (PZQ), foram investigados. Isto envolveu parâmetros imunológicos tais como IgM, IgG, Interleucina 2 e 6 (IL-2 e 6), fator de necrose tumoral (TNF-α) e algumas enzimas anti-oxidantes [catalase, super-óxido dismutase (SOD) e glutationa peroxidase (GPX)]. Em adição foram realizadas investigações parasitológicas e histopatológicas. Nenhuma alteração foi observada nos camundongos controles normais tratados com extrato seco de cebola ou alho, individualmente ou misturado, com ou sem PZQ, comparados com os controles normais sadios. Infecção com o Schistosoma mansoni revelou um aumento em IgG, IgM, IL-2, IL-6, TNF-α e catalase, acompanhados de diminuição do GPX e atividade enzimática do anti-oxidante SOD. Melhora acentuada foi notada nos níveis de todos os parâmetros medidos em camundongos infectados com Schistosoma mansoni após administração dos extratos estudados. Mais ainda, significante redução na quantidade de vermes, e ovos no fígado e intestino e na contagem do oograma foi notada refletindo a normalização da arquitetura do fígado.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Praziquantel / Schistosoma mansoni / Schistosomiasis mansoni / Plant Extracts / Onions / Garlic / Anthelmintics Type of study: Prognostic study Limits: Animals Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 2011 Type: Article

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Full text: Available Index: LILACS (Americas) Main subject: Praziquantel / Schistosoma mansoni / Schistosomiasis mansoni / Plant Extracts / Onions / Garlic / Anthelmintics Type of study: Prognostic study Limits: Animals Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 2011 Type: Article