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Frequency of the anti-glutamic acid decarboxylase immunological marker in patients with diabetes duration longer than three years in southern Brazil / Frequência do marcador imunológico de anti-decarboxilase do ácido glutâmico em pacientes com diabetes há mais de três anos no Sul do Brasil
Moreira, Marina Carolina; Lara, Gustavo Müller; Linden, Rafael; Feksa, Luciane Rosa; Tavares, Rejane Giacomelli; Almeida, Sabrina Esteves de Matos; Berlese, Daiane Bolzan.
  • Moreira, Marina Carolina; Universidade Feevale. Novo Hamburgo. BR
  • Lara, Gustavo Müller; Universidade Feevale. Laboratory Course for Undergraduate Biomedicine. Novo Hamburgo. BR
  • Linden, Rafael; Universidade Feevale. Institute of Health Sciences and Researcher. Novo Hamburgo. BR
  • Feksa, Luciane Rosa; Universidade Feevale. Institute of Health Sciences and Researcher. Novo Hamburgo. BR
  • Tavares, Rejane Giacomelli; Universidade Feevale. Institute of Health Sciences and Researcher. Novo Hamburgo. BR
  • Almeida, Sabrina Esteves de Matos; Universidade Feevale. Institute of Health Sciences and Researcher. Novo Hamburgo. BR
  • Berlese, Daiane Bolzan; Universidade Feevale. Novo Hamburgo. BR
São Paulo med. j ; 129(3): 130-133, May 2011. tab
Article in English | LILACS | ID: lil-592828
ABSTRACT
CONTEXT AND

OBJECTIVE:

The anti-GAD (glutamic acid decarboxylase) antibody is considered to be an important marker for type 1 diabetes mellitus (DM1), with frequency that varies depending on the population studied and the duration of the disease. Therefore, the aim of this study was to determine the frequency of this autoantibody in a group of patients in southern Brazil with DM1 that had been diagnosed more than three years previously. DESIGN AND

SETTING:

Analytical cross-sectional study with a control group conducted at the Biomedicine Laboratory of Universidade Feevale.

METHODS:

This study was conducted between June 2007 and December 2008, and 109 individuals were enrolled during this period. Fifty-eight were DM1 patients and 51 were individuals free from DM1 and without any history of diabetes, who constituted the control group.

RESULTS:

In the DM1 group, the mean age was 27 ± 1.7 years and 50 percent were men. The mean fasting blood glucose in the DM1 group was 208 ± 15 mg/dl and mean HbA1c (glycosylated hemoglobin) was 8.7 ± 0.25 percent. In the control group, the mean fasting blood glucose and HbA1c were 82 mg/dl and 5.0 percent respectively. Thirty-seven individuals with DM1 (63.8 percent) were positive for anti-GAD, and this proportion was significantly larger than in the control group.

CONCLUSIONS:

These results show the high prevalence of anti-GAD in the population of diabetic patients in southern Brazil, thus indicating that the antibody was still present a long time after the disease had been diagnosed.
RESUMO
CONTEXTO E

OBJETIVO:

O anticorpo anti-decarboxilase do ácido glutâmico (anti-GAD) é considerado um importante marcador no diabetes mellitus tipo 1 (DM1), cuja frequência varia segundo a população estudada e o tempo de duração da doença. Assim, o objetivo deste estudo foi determinar a frequência deste auto-anticorpo em um grupo de pacientes localizados no Sul do Brasil com mais de três anos de diagnóstico de DM1. TIPO DE ESTUDO E LOCAL Estudo transversal analítico com grupo controle, realizado no Laboratório de Biomedicina da Universidade Feevale.

MÉTODOS:

Este estudo foi realizado no período de Junho de 2007 a Dezembro de 2008, em que 109 indivíduos foram incluídos, sendo 58 destes com DM1 e 51 indivíduos sem DM1 e sem antecedentes de diabetes, que constituíram o grupo controle.

RESULTADOS:

No grupo DM1, a idade média foi 27 ± 1,7 anos e 50 por cento eram homens. A média da glicemia de jejum no grupo DM1 foi 208 ± 15 mg/dL e a HbA1c média foi 8,7 ± 0.25 por cento. No grupo controle a glicemia de jejum média e a HbA1c (hemoglobina glicosilada) foram 82 mg/dL e 5,0 por cento, respectivamente. O anti-GAD foi positivo em 37 (63,8 por cento) indivíduos com DM1, valores significativamente maiores quando comparados com os do grupo controle.

CONCLUSÕES:

Estes resultados mostram a alta prevalência do anti-GAD na população de pacientes diabéticos da região Sul do Brasil, indicando que o anticorpo está presente após um longo período de diagnóstico da doença.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Autoantibodies / Diabetes Mellitus, Type 1 / Glutamate Decarboxylase Type of study: Observational study / Prevalence study / Risk factors / Screening study Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Feevale/BR

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Full text: Available Index: LILACS (Americas) Main subject: Autoantibodies / Diabetes Mellitus, Type 1 / Glutamate Decarboxylase Type of study: Observational study / Prevalence study / Risk factors / Screening study Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Feevale/BR