Anticonvulsant activity of thymoquinone and its structural analogues
Rev. bras. farmacogn
;
21(3): 427-431, maio-jun. 2011. ilus, graf, tab
Article
in English
| LILACS
| ID: lil-593286
ABSTRACT
It has been widely reported that the crude oil of Nigella sativa L., Ranunculaceae, seeds and its major chemical component thymoquinone present anticonvulsant activity. These facts led us to verify the pharmacological potential of five structurally related para-benzoquinones on the pentylenotetrazol-induced seizures model, and establish the structural characteristics that influence the anticonvulsant activity of thymoquinone. The unsubstituted para-benzoquinone was the compound that exhibited the highest potency, while 2-methyl-p-benzoquinone was inactive. It was found that the presence of alkyl groups attached to the ring influence the pharmacological activity of the para-benzoquinones. In addition, the number, position, and size of these groups change the anticonvulsant potency of the compounds.
Full text:
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Index:
LILACS (Americas)
Type of study:
Prognostic study
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal da Paraíba/BR
/
Universidade Federal de Sergipe/BR
/
Universidade Federal de São Carlos/BR
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