The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration
Clinics
;
66(5): 743-746, 2011. tab
Article
in English
| LILACS
| ID: lil-593834
ABSTRACT
OBJECTIVE:
To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration.METHOD:
The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and 25 control subjects without age-related macular degeneration.RESULT:
The malondialdehyde and advanced oxidation protein product levels in the serum were significantly higher in the age-related macular degeneration patient group than in the control group (p<0.05). The superoxide dismutase activity in the serum was significantly lower in the age-related macular degeneration patient group than in the control group (p<0.05). The levels of vitamin C and glutathione and the activity of glutathione peroxidase in the serum were unchanged between groups (p>0.05).CONCLUSION:
The results of the present study suggest that decreased effectiveness of the antioxidant defense system and increased oxidative stress may play a role in the pathogenesis of age-related macular degeneration.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Superoxide Dismutase
/
Lipid Peroxidation
/
Oxidative Stress
/
Choroidal Neovascularization
/
Glutathione Peroxidase
/
Macular Degeneration
Type of study:
Etiology study
/
Observational study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2011
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Ankara Numune Education and Research Hospital/TR
/
Duatepe Government Hospita/TR
/
Etimesgut Public Health Laboratory/TR
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