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Suppressed induction and expression of delayed hypersensitivity responses in BALB/c mice infected with trypanosoma venezuelense
Acta cient. venez ; 38(1): 73-6, 1987. ilus, tab
Article in English | LILACS | ID: lil-59428
RESUMO
Following inoculation with 1x10E4 trypomastigotes of Trypanosome venezuelense BALB/c mice showed a progressive, fatal parasitemia and an impaired capability to develop delayed hypersensitivity responses (DHR) as induced by IV immunization with sheep red blood cells (SRBC). Depressed DHR were seen in mice immunized at the time of inoculation and challenged 4 days later. A local cell transfer of immune cells at the site of challenge in the footpad showed that T cells obtained from infected mice immunized with an optimal dose of SRBC on the day of inoculation failed to transfer DHR to naive recipients. However, significant DHR were transfered by T cells from infected mice immunized with a sub-optimal dose of SRBC. By the other hand, 4 days-infected- mice receiving a local transfer of immune T cells taken from non-infected donors failed to express DHR ascompared to controls. It is suggested that in BALB/c mice infected with T. venezuelense both the induction and expression of DHR are impared
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Index: LILACS (Americas) Main subject: Trypanosoma / Hypersensitivity, Delayed Limits: Animals Language: English Journal: Acta cient. venez Journal subject: Science Year: 1987 Type: Article

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Index: LILACS (Americas) Main subject: Trypanosoma / Hypersensitivity, Delayed Limits: Animals Language: English Journal: Acta cient. venez Journal subject: Science Year: 1987 Type: Article