Urban, traffic- related particles and lung tumors in urethane treated mice
Clinics
;
66(6): 1051-1054, 2011. ilus, graf
Article
in English
| LILACS
| ID: lil-594377
ABSTRACT
OBJECTIVE:
The present study was designed to evaluate the effects of urban, traffic-related, fine particulate matter (PM2.5) on mice lung tumorigenesis under controlled exposure conditions.METHODS:
Four groups of female Swiss mice were treated with intraperitonial injections of urethane and saline solution. Urethane was used to start the carcinogenesis process. The animals were housed in two chambers receiving filtered and polluted air. In the polluted air chamber, pollutant levels were low. After two months of exposure, the animals were euthanized and lung tumoral nodules were counted.RESULTS:
Saline-treated animals showed no nodules. Urethane-treated animals showed 2.0+2.0 and 4.0+3.0 nodules respectively, in the filtered and non-filtered chambers (p = 0.02), thus showing experimental evidence of increased carcinogenic-induced lung cancer with increasing PM2.5 exposure.CONCLUSION:
Our data support the concept that low levels of PM2.5 may increase the risk of developing lung tumors.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Air Pollutants
/
Lung Neoplasms
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Animals
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
/
University of São Paulo/BR
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