Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cell
Biocell
;
33(2): 107-114, Aug. 2009. tab, graf
Article
in English
| LILACS
| ID: lil-595035
ABSTRACT
Cyclooxygenase-2 (COX-2) is a key inflammatory response molecule, and associated with many immune functions of monocytes/macrophages. Particularly, interferon gamma (IFNgamma)-induced COX-2 expression appears in inflammatory conditions such as viral infection and autoimmune diseases. Recently, statins have been reported to show variable effects on COX-2 expression, and on their cell and species type dependences. Based on the above description, we compared the effect of simvastatin on IFNgamma-induced COX-2 expression in human monocytes versus murine macrophages. In a result, we found that simvastatin suppresses IFNgamma-induced COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNgamma-induced COX-2 expression in murine RAW264.7 macrophages. However, signal transducer and activator of transcriptio n 1/3 (STAT1/3), known as a transcription factor on COX-2 expression, is inactivated by simvastatin in both cells. Our findings showed that simvastatin is likely to suppress IFNgamma-induced COX-2 expression by inhibiting STAT1/3 activation in human THP-1 cells, but not in murine RAW264.7 cells. Thus, we concluded that IFNgamma-induced COX-2 expression is differently regulated by simvastatin depending on species specific mechanism.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
RNA, Messenger
/
Monocytes
/
Macrophages
Limits:
Animals
/
Humans
Language:
English
Journal:
Biocell
Journal subject:
Clulas
Year:
2009
Type:
Article
Affiliation country:
South Korea
Institution/Affiliation country:
Seoul National University/KR
/
Sungkyunkwan University/KR
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