CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity
Biocell
;
34(2): 91-94, Aug. 2010. ilus, graf
Article
in English
| LILACS
| ID: lil-595038
ABSTRACT
CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Leukemia, Myeloid
/
Cell Movement
/
Cell Surface Extensions
Limits:
Humans
Language:
English
Journal:
Biocell
Journal subject:
Clulas
Year:
2010
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
China Medical University/CN
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