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NFAT regulates CSF-1 gene transcription triggered by L-selectin crosslinking
Chen, Cuixia; Cui, Lingling; Shang, Xin; Zeng, Xianlu.
  • Chen, Cuixia; China University of Petroleum (East China). Centre for Bioengineering and Biotechnology. Qingdao. CN
  • Cui, Lingling; Northeast Normal University. Institute of Genetics and Cytology. Changchun. CN
  • Shang, Xin; Northeast Normal University. Institute of Genetics and Cytology. Changchun. CN
  • Zeng, Xianlu; Northeast Normal University. Institute of Genetics and Cytology. Changchun. CN
Biocell ; 34(2): 57-63, Aug. 2010. graf
Article in English | LILACS | ID: lil-595039
ABSTRACT
L-selectin is a member of the selectin family that play an important role both in mediating the initial capture and subsequent rolling of leukocytes along the endothelial cells. Furthermore, L-selectin can function as a signal molecule. In our previous studies, we reported that L-selectin ligation could regulate CSF-1 (colony-stimulating factor-1) gene transcription, in which AP-1 acts as a crucial transcriptional factor. Here we investigated the function of the NFAT in the CSF-1 gene transcriptional events. We found that overexpression of WT NFAT induce CSF-1 gene transcription greatly in the activated Jurkat cells. Furthermore, we found that NFAT can be recruited to the nucleus after L-selectin ligation, and the nuclear NFAT interacts with the CSF-1 promoter region to regulate CSF-1 gene transcription in the L-s electin ligation activated Jurkat cells. These results indicate that nuclear NFAT can activate CSF-1 gene transcription by connecting with the CSF-1 promoter in the signaling events induced by L-selectin ligation.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: T-Lymphocytes / L-Selectin / Jurkat Cells / NFATC Transcription Factors / Macrophages Limits: Animals / Humans Language: English Journal: Biocell Journal subject: C‚lulas Year: 2010 Type: Article Affiliation country: China Institution/Affiliation country: China University of Petroleum (East China)/CN / Northeast Normal University/CN

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Full text: Available Index: LILACS (Americas) Main subject: T-Lymphocytes / L-Selectin / Jurkat Cells / NFATC Transcription Factors / Macrophages Limits: Animals / Humans Language: English Journal: Biocell Journal subject: C‚lulas Year: 2010 Type: Article Affiliation country: China Institution/Affiliation country: China University of Petroleum (East China)/CN / Northeast Normal University/CN