Interleukin-1 beta regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
Biocell
;
34(1): 37-43, Apr. 2010. graf
Article
in English
| LILACS
| ID: lil-595048
ABSTRACT
Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-beta on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1 beta activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Embryo Implantation
/
Trophoblasts
/
Cytokines
/
Leptin
/
Matrix Metalloproteinase 9
/
Interleukin-1beta
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Biocell
Journal subject:
Clulas
Year:
2010
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad de Buenos Aires/AR
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