Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
Braz. j. infect. dis
;
15(4): 377-381, July-Aug. 2011. tab
Article
in English
| LILACS
| ID: lil-595681
ABSTRACT
OBJECTIVE:
To investigate the frequency of thyroid disorders (TD) in patients with chronic hepatitis C before and during interferon-alpha (IFN-α) and ribavirin (RIB) treatment. STUDYDESIGN:
Prospective study. PATIENTS ANDMETHODS:
We prospectively studied 65 anti-HCV and viral RNA positive patients. Free thyroxine, thyroid-stimulating hormone, and thyroid peroxidase antibodies (TPO-Ab) were systematically tested at entry (m0), week 12 (m3) and week 24 (m6) of treatment.RESULTS:
Mean age of the 65 patients (38 females and 27 males) was 49.61 ± 11.83 years. Seven (10.76 percent) patients presented baseline thyroid disorders (m0), three had thyroid dysfunction, and four were TPO-Ab positive. Thyroid disorders occurred in the first 12 weeks of treatment in 11 (16.92 percent) patients, four with thyroid dysfunction, and seven with TPO-Ab positive (m3). A total of 18 patients (27.69 percent) developed TD after 24 weeks of treatment, 7 with thyroid dysfunction, and 11 with TPO-Ab positive (m6). The relative risk of developing hypothyroidism found in this study was 1.3 (95 percent CI 1.1 to 1.6), hyperthyroidism 1.2 (95 percent CI 1.1 to 1.4), and TPO-Ab positivity 7.6 (95 percent CI 3.9 to 14.5). The study showed a significant association between female sex and thyroid disease (p = 0.009).CONCLUSION:
Thyroid dysfunction and autoimmune TD were observed during IFN-α and RIB therapy.
Full text:
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Index:
LILACS (Americas)
Main subject:
Antiviral Agents
/
Ribavirin
/
Thyroid Diseases
/
Interferon-alpha
/
Hepatitis C, Chronic
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UFBA/BR
/
Universidade Estadual de Santa Cruz/BR
/
Universidade Federal da Bahia/BR
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