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Characterization and analysis of the outcome of adults with acute myeloid leukemia treated in a Brazilian University hospital over three decades
Souto Filho, J. T; Portugal, R. D; Loureiro, M; Pulcheri, W; Nucci, M.
  • Souto Filho, J. T; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro. BR
  • Portugal, R. D; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro. BR
  • Loureiro, M; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro. BR
  • Pulcheri, W; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro. BR
  • Nucci, M; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro. BR
Braz. j. med. biol. res ; 44(7): 660-665, July 2011. ilus, tab
Article in English | LILACS | ID: lil-595706
ABSTRACT
We evaluated the outcome of 227 patients with acute myeloid leukemia during three decades (period 1 - 1980’s, N = 89; period 2 - 1990’s, N = 73; period 3 - 2000’s, N = 65) at a single institution. Major differences between the three groups included a higher median age, rates of multilineage dysplasia and co-morbidities, and a lower rate of clinical manifestations of advanced leukemia in recent years. The proportion of patients who received induction remission chemotherapy was 66, 75, and 85 percent for periods 1, 2, and 3, respectively (P = 0.04). The median survival was 40, 77, and 112 days, and the 5-year overall survival was 7, 13, and 22 percent, respectively (P = 0.01). The median disease-free survival was 266, 278, and 386 days (P = 0.049). Survival expectation for patients with acute myeloid leukemia has substantially improved during this 30-year period, due to a combination of lower tumor burden and a more efficient use of chemotherapy and supportive care.
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Full text: Available Index: LILACS (Americas) Main subject: Leukemia, Myeloid, Acute / Hospitalization Type of study: Evaluation studies / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio de Janeiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Leukemia, Myeloid, Acute / Hospitalization Type of study: Evaluation studies / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio de Janeiro/BR