Determination of beta S haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil
Genet. mol. biol
;
34(3): 421-424, 2011. tab
Article
in English
| LILACS
| ID: lil-595989
ABSTRACT
βS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5 percent) were identified with genotype CAR/CAR, 9 (19.1 percent) CAR/BEN, 6 (12.8 percent) CAR/CAM, 1 (2.1 percent) BEN/BEN, 2 (4.3 percent) CAR/Atp, 1 (2.1 percent) BEN/Atp and 1 (2.1 percent) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte.
Full text:
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Index:
LILACS (Americas)
Main subject:
Haplotypes
/
Beta-Globins
/
Anemia, Sickle Cell
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hemocentro Dalton Barbosa Cunha/BR
/
Universidade Estadual de Campinas/BR
/
Universidade Federal do Rio Grande do Norte/BR
/
Universidade do Estado do Rio Grande do Norte/BR
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