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Biochemical recurrence after radical prostatectomy: is the disease or the surgeon to blame?
Simsir, Adnan; Cal, Cag; Mammadov, Rashad; Cureklibatir, Ibrahim; Semerci, Bulent; Gunaydin, Gurhan.
  • Simsir, Adnan; Ege University Medical Faculty. Department of Urology. Izmir. TR
  • Cal, Cag; Ege University Medical Faculty. Department of Urology. Izmir. TR
  • Mammadov, Rashad; Ege University Medical Faculty. Department of Urology. Izmir. TR
  • Cureklibatir, Ibrahim; Ege University Medical Faculty. Department of Urology. Izmir. TR
  • Semerci, Bulent; Ege University Medical Faculty. Department of Urology. Izmir. TR
  • Gunaydin, Gurhan; Ege University Medical Faculty. Department of Urology. Izmir. TR
Int. braz. j. urol ; 37(3): 328-335, May-June 2011. tab
Article in English | LILACS | ID: lil-596007
ABSTRACT

PURPOSE:

The PSA recurrence develops in 27 to 53 percent within ten years after radical prostatectomy (RP). We investigated the factors (disease grade and stage or the surgeon's expertise,) more likely to influence biochemical recurrence in men post-radical prostatectomy for organ-confined prostate cancer by different surgeons in the same institution. MATERIALS AND

METHODS:

A total of 510 patients that underwent radical prostatectomy were investigated retrospectively. Biochemical recurrence was defined as detection of a PSA level of > 0.20 ng/mL by two subsequent measurements. The causes, which are likely to influence the development of PSA recurrence, were separated into two groups as those related to the disease and those related to the surgical technique.

RESULTS:

Biochemical recurrence was detected in 23.5 percent (120 cases) of 510 cases. The parameters most likely to influence biochemical recurrence were PSA level (p < 0.0001), T stage (p < 0.0001), the presence of extracapsular invasion prostate (p < 0.0001), Gleason scores (p = 0.042, p < 0.0001) and the presence of biopsy with perineural invasion (p = 0.03). The only surgical factor that demonstrated relevance was inadvertent capsular incision during the surgery that influenced the PSA recurrence (p < 0.0001).

CONCLUSION:

The PSA recurrence was detected in 21.6 percent of patients who had been treated with radical prostatectomy within 5 years, which indicates that the parameters related to the disease and the patient have a pivotal role in the PSA recurrence.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Prostatectomy / Prostatic Neoplasms / Urology / Prostate-Specific Antigen / Neoplasm Recurrence, Local Type of study: Etiology study / Observational study Limits: Adult / Aged / Aged80 / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2011 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ege University Medical Faculty/TR

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Full text: Available Index: LILACS (Americas) Main subject: Prostatectomy / Prostatic Neoplasms / Urology / Prostate-Specific Antigen / Neoplasm Recurrence, Local Type of study: Etiology study / Observational study Limits: Adult / Aged / Aged80 / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2011 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ege University Medical Faculty/TR