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Chemical composition and antiproliferative activity of essential oil from aerial parts of a medicinal herb Artemisia herba-alba
Tilaoui, Mounir; Mouse, Hassan Ait; Jaafari, Abdeslam; Aboufatima, Rachida; Chait, Abderrahman; Zyad, Abdelmajid.
  • Tilaoui, Mounir; Sultan Moulay Slimane University. Faculty of Sciences and Technologies. Natural Substances, Cellular and Molecular Immuno-pharmacology Group. Laboratory of Biological Engineering. MA
  • Mouse, Hassan Ait; Sultan Moulay Slimane University. Faculty of Sciences and Technologies. Natural Substances, Cellular and Molecular Immuno-pharmacology Group. Laboratory of Biological Engineering. MA
  • Jaafari, Abdeslam; Sultan Moulay Slimane University. Faculty of Sciences and Technologies. Natural Substances, Cellular and Molecular Immuno-pharmacology Group. Laboratory of Biological Engineering. MA
  • Aboufatima, Rachida; Cadi Ayyad University. Faculty of Sciences Semlalia. Laboratory of Ecophysiology. MA
  • Chait, Abderrahman; Cadi Ayyad University. Faculty of Sciences Semlalia. Laboratory of Ecophysiology. MA
  • Zyad, Abdelmajid; Sultan Moulay Slimane University. Faculty of Sciences and Technologies. Natural Substances, Cellular and Molecular Immuno-pharmacology Group. Laboratory of Biological Engineering. MA
Rev. bras. farmacogn ; 21(4): 781-785, jul.-ago. 2011. ilus, graf, tab
Article in English | LILACS | ID: lil-596247
ABSTRACT
Artemisia herba-alba Asso., Asteraceae, is widely used in Morrocan folk medicine for the treatment of different health disorders. However, no scientific or medical studies were carried out to assess the cytotoxicity of A. herba-alba essential oil against cancer cell lines. In this study, eighteen volatile compounds were identified by GC-MS analysis of the essential oil obtained from the plant's aerial parts. The main volatile constituent in A. herba-alba was found to be a monoterpene, Verbenol, contributing to about 22 percent of the total volatile components. The essential oil showed significant antiproliferative activity against the acute lymphoblastic leukaemia (CEM) cell line, with 3 µg/mL as IC50 value. The anticancer bioactivity of Moroccan A. herba-alba essential oil is described here for the first time.


Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2011 Type: Article Affiliation country: Morocco Institution/Affiliation country: Cadi Ayyad University/MA / Sultan Moulay Slimane University/MA

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Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2011 Type: Article Affiliation country: Morocco Institution/Affiliation country: Cadi Ayyad University/MA / Sultan Moulay Slimane University/MA