Advances in haploidentical stem cell transplantation
Rev. bras. hematol. hemoter
;
33(3): 237-241, June 2011.
Article
in English
| LILACS
| ID: lil-596328
ABSTRACT
Hematopoietic stem cell transplantation from haploidentical donors is an attractive method of transplantation due to the immediate donor availability, ease of stem cell procurement and the possibility to collect additional donor cells for cellular therapy, if needed. Historically, maintaining T-cells in the graft has been associated with very high rates of graft-versus-host disease, while T-cell depleted haploidentical transplantation has been limited by a higher incidence of graft rejection and delayed immune reconstitution post-transplant. Recent approaches attempt to maintain the T-cells in the graft while effectively preventing the development of graft-versus-host disease post-transplant. Selective depletion of alloreactive T-cells post-transplant using high-dose post-transplant cyclophosphamide is under investigation as a promising alternative in haploidentical transplantation. While engraftment has improved and graft-versus-host disease is controlled with this approach, future directions should focus on optimizing conditioning regimens and the prevention of disease relapse post-transplant.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
T-Lymphocytes
/
Bone Marrow Transplantation
/
Hematopoietic Stem Cell Transplantation
/
Hematologic Neoplasms
Limits:
Humans
Language:
English
Journal:
Rev. bras. hematol. hemoter
Journal subject:
Hematology
Year:
2011
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
The University of Texas M.D/US
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