On cytoadhesion of Plasmodium vivax: raison d'être?
Mem. Inst. Oswaldo Cruz
;
106(supl.1): 79-84, Aug. 2011. ilus, tab
Article
in English
| LILACS
| ID: lil-597247
ABSTRACT
It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.
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Index:
LILACS (Americas)
Main subject:
Plasmodium vivax
/
Malaria, Vivax
/
Erythrocytes
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2011
Type:
Article
Affiliation country:
Brazil
/
Spain
Institution/Affiliation country:
Fundação de Medicina Tropical Doutor Heitor Vieira/BR
/
Instituto Leônidas e Maria Deane-Fiocruz/BR
/
Universidade Estadual de Campinas/BR
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