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Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development
Tse, Sze-Wah; Radtke, Andrea J; Zavala, Fidel.
  • Tse, Sze-Wah; Johns Hopkins University. Johns Hopkins Malaria Research Institute. Johns Hopkins Bloomberg School of Public Health. Department of Molecular Microbiology and Immunology.
  • Radtke, Andrea J; Johns Hopkins University. Johns Hopkins Malaria Research Institute. Johns Hopkins Bloomberg School of Public Health. Department of Molecular Microbiology and Immunology.
  • Zavala, Fidel; Johns Hopkins University. Johns Hopkins Malaria Research Institute. Johns Hopkins Bloomberg School of Public Health. Department of Molecular Microbiology and Immunology.
Mem. Inst. Oswaldo Cruz ; 106(supl.1): 172-178, Aug. 2011.
Article in English | LILACS | ID: lil-597259
ABSTRACT
CD8+ T cells against malaria liver stages represent a major protective immune mechanism against infection. Following induction in the peripheral lymph nodes by dendritic cells (DCs), these CD8+ T cells migrate to the liver and eliminate parasite infected hepatocytes. The processing and presentation of sporozoite antigen requires TAP mediated transport of major histocompatibility complex class I epitopes to the endoplasmic reticulum. Importantly, in DCs this process is also dependent on endosome-mediated cross presentation while this mechanism is not required for epitope presentation on hepatocytes. Protective CD8+ T cell responses are strongly dependent on the presence of CD4+ T cells and the capacity of sporozoite antigen to persist for a prolonged period of time. While human trials with subunit vaccines capable of inducing antibodies and CD4+ T cell responses have yielded encouraging results, an effective anti-malaria vaccine will likely require vaccine constructs designed to induce protective CD8+ T cells against malaria liver stages.
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Full text: Available Index: LILACS (Americas) Main subject: Hepatocytes / Liver / Malaria / Antigens, Protozoan Limits: Animals / Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2011 Type: Article Affiliation country: United States

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Full text: Available Index: LILACS (Americas) Main subject: Hepatocytes / Liver / Malaria / Antigens, Protozoan Limits: Animals / Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2011 Type: Article Affiliation country: United States