Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal / Hypovitaminosis D in pediatric patients on renal replacement therapy
Rev. méd. Chile
;
139(3): 334-339, mar. 2011. ilus
Article
in Spanish
| LILACS
| ID: lil-597622
ABSTRACT
Background:
Hypovitaminosis D has a high prevalence among patients with chronic kidney disease (CKD).Aim:
To determine the prevalence of 25 hydroxy vitamin D (25(OH) D) insufficiency and deficiency in pediatric patients on dialysis and kidney transplantation. Material andMethods:
Serum calcium and phosphorus, parathormone (PTH), alkaline phosphatases and 25 (OH)D were measured in 13 children on hemodialysis (HD), 18 on peritoneal dialysis (PD) and 53 that received an allograft (Tx), aged 9.8 ± 4.6 years (51 percent females).Results:
Fifty four percent of patients had height Z score less than -1.88. Patients on HD had the lowest values. The average time of replacement therapy was 2.9 ± 2.8 years. Mean 25(OH)D levels in all was 18.7 ± 10.7ng/ml (HD 21 ± 16.8, PD 18.9 ± 8.5, Tx 18.1 ± 9.72 ng/ml). Eighty eight percent of patients had levels below 30 ng/ml. Mean of serum calcium was 9.5 ± 0.64 mg/dl, serum phosphorus 5.03 ± 1.02 mg/dl, calcium-phosphorus product 48 ± 11.8 mg/dl and alkaline phosphatases 300.5 ± 171.3 IU/L. Average PTH values in dialyzed and Tx patients were 724.6 ± 640.5 and 107.7 ± 56.2 pg/ml, respectively (p < 0.001). A positive correlation between 25 (OH) D and calcium levels among PD patients was observed (r = 0.490, p = 0.04).Conclusions:
Hypovitaminosis D is highly prevalent among children on renal substitution therapy, regardless of the type of therapy used and the stage of renal failure.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vitamin D Deficiency
/
Renal Replacement Therapy
/
Kidney Failure, Chronic
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Child
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2011
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
/
Universidad de Chile, Hospital Luis Calvo Mackenna/CL
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