Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
Mem. Inst. Oswaldo Cruz
;
106(5): 617-619, Aug. 2011. ilus, graf
Article
in English
| LILACS
| ID: lil-597723
ABSTRACT
The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.
Full text:
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Index:
LILACS (Americas)
Main subject:
Strongyloides
/
Strongyloidiasis
/
Intestinal Diseases, Parasitic
/
Mycobacterium bovis
/
Mycobacterium Infections
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Juiz de Fora/BR
/
Universidade Federal de Minas Gerais/BR
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