Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region
Mem. Inst. Oswaldo Cruz
;
106(5): 629-631, Aug. 2011. tab
Article
in English
| LILACS
| ID: lil-597726
ABSTRACT
We report two ciprofloxacin and ofloxacin-resistant Neisseria gonorrhoeae strains that were isolated from the urethral discharge of male patients at the sexually transmitted diseases outpatient clinic of the Alfredo da Matta Foundation (Manaus, state of Amazonas, Brazil). The gonococci displayed minimal inhibitory concentrations (> 32.00 µg/mL) and three mutations in the quinolone resistance-determining region (S91F and D95G in GyrA and S87R in ParC). Both isolates were genotyped using N. gonorrhoeae multi-antigen sequence typing and the analysis showed that the ST225 which represented an emerging widespread multi-resistant clone that has also been associated with reduced susceptibility to ceftriaxone. We recommend continued surveillance of this pathogen to assess the efficacy of anti-gonococcal antibiotics in Brazil.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Ofloxacin
/
Ciprofloxacin
/
Gonorrhea
/
Drug Resistance, Bacterial
/
Anti-Bacterial Agents
/
Neisseria gonorrhoeae
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fiocruz/BR
/
Fundação de Hematologia e Hemoterapia do Amazonas/BR
/
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado/BR
/
Universidade Estadual do Amazonas/BR
/
Universidade Federal do Amazonas/BR
Similar
MEDLINE
...
LILACS
LIS