Your browser doesn't support javascript.
loading
Triorganotin as a compound with potential reproductive toxicity in mammals
Delgado Filho, V. S; Lopes, P. F. I; Podratz, P. L; Graceli, J. B.
  • Delgado Filho, V. S; Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Biologia Celular do Envelhecimento. Vitória. BR
  • Lopes, P. F. I; Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Biologia Celular do Envelhecimento. Vitória. BR
  • Podratz, P. L; Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Biologia Celular do Envelhecimento. Vitória. BR
  • Graceli, J. B; Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Morfologia. Laboratório de Biologia Celular do Envelhecimento. Vitória. BR
Braz. j. med. biol. res ; 44(9): 958-965, Sept. 2011. ilus
Article in English | LILACS | ID: lil-599669
ABSTRACT
Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Organotin Compounds / Trialkyltin Compounds / Genitalia / Mammals Limits: Animals / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2011 Type: Article / Congress and conference Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Espírito Santo/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Organotin Compounds / Trialkyltin Compounds / Genitalia / Mammals Limits: Animals / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2011 Type: Article / Congress and conference Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Espírito Santo/BR