Hydroxyapatite crystallinity does not affect the repair of critical size bone defects
J. appl. oral sci
;
19(4): 337-342, July-Aug. 2011. ilus, tab
Article
in English
| LILACS
| ID: lil-599756
ABSTRACT
OBJECTIVE:
The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo. MATERIAL ANDMETHODS:
The HA granules were produced in the Biomaterials Laboratory (COPPE/UFRJ). The testing materials were HA granules presenting a Ca/P molar ratio of 1.60 and 28 percent crystallinity (HA-1), and a Ca/P molar ratio of 1.67 and 70 percent crystallinity (HA-2). Both HAs were implanted into a critical-size calvaria rat defects.RESULTS:
To note, in the control group, the bone defects were filled with blood clot only. Descriptive and histomorphometric analyses after 1, 3, and 6 months postoperatively showed mild inflammatory infiltrate, mainly comprising macrophage-like and multinucleated giant cells, and an increase in the volume density of the fibrous tissues (p<0.05), which was in contrast to the similar volume density of the newly formed bone and biomaterials in relation to the control group.CONCLUSION:
Thus, we concluded that HA-1 and HA-2 are biocompatible and non-degradable, and that crystallinity does not affect bone repair of critical size defects.
Full text:
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Index:
LILACS (Americas)
Main subject:
Skull
/
Biocompatible Materials
/
Bone Regeneration
/
Durapatite
/
Bone Substitutes
Limits:
Animals
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Rio de Janeiro/BR
/
Fluminense Federal University/BR
/
Unigranrio University/BR
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