Comparison between the effects of platelet-rich plasma and bone marrow concentrate on defect consolidation in the rabbit tibia
Clinics
;
66(10): 1787-1792, 2011. ilus, tab
Article
in English
| LILACS
| ID: lil-601914
ABSTRACT
OBJECTIVE:
To perform a comparative analysis of the effects of platelet-rich plasma and centrifuged bone marrow aspirate on the induction of bone healing in rabbits.METHOD:
Twenty adult, male New Zealand rabbits were randomly separated into two equal groups, and surgery was performed to create a bone defect (a cortical orifice 3.3 mm in diameter) in the proximal metaphysis of each rabbit's right tibia. In the first group, platelet-rich plasma was implanted in combination with β-tricalcium phosphate (platelet-rich plasma group), and in the second group, centrifuged bone marrow in combination with β-tricalcium phosphate (centrifuged bone marrow group) was implanted. After a period of four weeks, the animals were euthanized, and the tibias were evaluated using digital radiography, computed tomography, and histomorphometry.RESULTS:
Seven samples from each group were evaluated. The radiographic evaluation confirmed the absence of fractures in the postoperative limb and identified whether bone consolidation had occurred. The tomographic evaluation revealed a greater amount of consolidation and the formation of a greater cortical bone thickness in the platelet-rich plasma group. The histomorphometry revealed a greater bone density in the platelet-rich plasma group compared with the centrifuged bone marrow group.CONCLUSION:
After four weeks, the platelet-rich plasma promoted a greater amount of bone consolidation than the bone marrow aspirate concentrate.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Osteogenesis
/
Tibia
/
Wound Healing
/
Bone Marrow Cells
/
Fracture Healing
/
Platelet-Rich Plasma
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Londrina/BR
/
Universidade de São Paulo/BR
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