The secretory effect of canatoxina ou rat brain synaptosomes involves a lipoxygenase-mediated pathway
Braz. j. med. biol. res
;
21(3): 549-52, Mar. 1988. ilus
Article
in English
| LILACS
| ID: lil-60248
RESUMO
Canatoxin (CNTX), a neurotoxic protein, is known to activate platelet secretion and aggregation in vitro through a lipoxygenase-dependent pathway. This study shows that CNTX also induces time and dose-dependent serotonin secretion from rat brain synaptosomes. The secretory effect induced by 6 micronM CNTX was similar to that elicited by 150 mM KCl. Nordihyderoguaiaretic acid (500 micronM) completely abolished CNTX-induced serotonin release while 150 micronM indomethacin had no effect. These data suggest the involvement of the lipoxygenase pathway in neurotransmitter release elicited by CNTX as occurs in the platelet
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Index:
LILACS (Americas)
Main subject:
Synaptosomes
/
In Vitro Techniques
/
Masoprocol
/
Brain
/
Serotonin
/
Lectins
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1988
Type:
Article
/
Congress and conference
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