The effect of diphenylhydantoin on spreading depression
Braz. j. med. biol. res
;
21(3): 603-5, Mar. 1988. tab
Article
in English
| LILACS
| ID: lil-60253
ABSTRACT
The present study examines the effect of diphenylhydantoin on the elicitation by K+ and propagation of spreading depression in chick retina preparations in vitro. A dose-related decrease in the velocity of propagation was observed, this effect being lessened by increasing the pH of the Ringer bathing the preparation. Changes in Ringer C1- concentration also altered the efficacy of the drug, higher concentrations enhancing and lower concentrations reducing efficacy. The threshold concentration of K+ necessary to elicit the reaction was elevated by dyphenylhydantoin
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Index:
LILACS (Americas)
Main subject:
Phenytoin
/
Potassium
/
Retina
/
Cortical Spreading Depression
/
In Vitro Techniques
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1988
Type:
Article
/
Congress and conference
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