Portal flow and mitochondrial function during extrahepatic cholestasis
Braz. j. med. biol. res
;
21(3): 637-40, Mar. 1988. tab
Article
in English
| LILACS
| ID: lil-60262
ABSTRACT
This study was designed to determine portal blood flow and mitochondrial and hepatic function during extrahepatic obstruction. Twenty-two male Wistar rats which had undergone bile duct ligation were compared 7 days later to 20 sham-operated controls. Portal flow and mitochondrial respiratory control ratio were reduced by 50% and 35%, respectively (P < 0.01), and serum alanine-aminotransferase levels increased significantly (P < 0.01) in the extrahepatic cholestatic group. These results suggest that cholestasis may cause an imbalance between the energy supply and the high demand of the liver leading to a state of partial ischemia
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Index:
LILACS (Americas)
Main subject:
Portal System
/
Cholestasis, Extrahepatic
/
Ischemia
/
Liver
/
Mitochondria
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1988
Type:
Article
/
Congress and conference
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