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Changes in the volume and histology of endometriosis foci in rats treated with copaiba oil (Copaiferalangsdorffii) / Mudanças no volume e histologia do foco de endometriose em ratas tratadas com óleo de Copaíba (Copaiferalangsdorffii)
Nogueira Neto, João; Lindoso, Márcio Jorge de Souza; Coelho, Laura Fernandes; Carvalho, Rafael Antonio Freire; Rodrigues, Taciana Gabrielle Pinheiro de Moura; Araújo, Ana Gisélia Portela de; Girão, Manuel João Batista Castelo; Schor, Eduardo.
  • Nogueira Neto, João; s.af
  • Lindoso, Márcio Jorge de Souza; UFMA. Maranhao. BR
  • Coelho, Laura Fernandes; UFMA. Maranhao. BR
  • Carvalho, Rafael Antonio Freire; UFMA. Maranhao. BR
  • Rodrigues, Taciana Gabrielle Pinheiro de Moura; UFMA. Maranhao. BR
  • Araújo, Ana Gisélia Portela de; s.af
  • Girão, Manuel João Batista Castelo; s.af
  • Schor, Eduardo; s.af
Acta cir. bras ; 26(supl.2): 20-24, 2011. ilus, tab
Article in English | LILACS | ID: lil-602639
ABSTRACT

PURPOSE:

The aim of this study was to analyze the changes that occur in rats with experimental endometriosis after treatment with copaiba oil.

METHODS:

Experimental endometriosis was induced in rats. The experimental group received copaiba oil (Copaiferalangsdorffii) orally (0.63 mg/day), and the control group received a 0.9 percent sodium chloride solution orally (1 ml/100 g of body weight/day). Both groups were treated with gavage for 14 days. After this period, the animals were euthanized, and the implant volume was calculated. The autologous transplants were removed, dyed with hematoxylin-eosin, and analyzed by light microscopy.

RESULTS:

The average final volumes were significantly different between the groups (p=0.007). There was a significant increase (p=0.012) between the initial and final volumes in the control group, whereas treatment with Copaiferalangsdorffii caused a marked reduction in endometrial growth over time (p=0.016). Histologically, 6/11 (55.00 percent) rats in the experimental group had a well-preserved epithelial layer, and 3 (45.00 percent) had mildly preserved epithelium. The control group had seven cases (58.30 percent) of well-preserved epithelial cells and five cases (41.70 percent) of mildly preserved epithelial cells (p>0.05).

CONCLUSION:

Copaiba oil (Copaiferalangsdorffii) appears to be a promising alternative treatment for endometriosis.
RESUMO

OBJETIVO:

O objetivo deste estudo foi analisar as mudanças que ocorreram em ratas com endometrioses experimental tratadas com óleo de copaíba.

MÉTODOS:

Foi induzida a endometriose experimental nas ratas. O grupo experimental recebeu óleo de copaíba (Copaiferalangsdorffii) oralmente (0,63mg/dia) e o grupo controle recebeu oralmente solução salina 0,9 por cento (1mL/100g/dia). Ambos grupos foram tratados por gavagem por 14 dias. Depois desse período, foi realizada a eutanásia dos animais e calculado o volume do implante. Os transplantes autólogos foram removidos, corados com Hematoxilina-eosina e realizada a microscopia óptica.

RESULTADOS:

A média final dos volumes foi significativamente diferente entre os grupos (p=0,007). Houve um aumente significante (p=0,12) entre o volume inicial e final do grupo controle, enquanto no grupo tratado com Copaiferalangsdorffii causou uma redução acentuada no crescimento endometrial ao longo durante o período (p=0,016). Histologicamente,6 das 11 (55 por cento) ratas do grupo experimental tinha uma camada epitelial bem preservada e 3 (45 por cento) apresentaram epitélio levemente preservado. O grupo controle apresentou sete casos (58,3 por cento) de células epiteliais bem preservadas e cinco casos (41,7 por cento) de células epiteliais levemente preservadas (p>0,05).

CONCLUSÃO:

O óleo de copaíba (Copaiferalangsdorffii) parece ser um tratamento alternativo promissor para endometriose.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Plant Oils / Plant Preparations / Endometriosis Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: UFMA/BR

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Full text: Available Index: LILACS (Americas) Main subject: Plant Oils / Plant Preparations / Endometriosis Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2011 Type: Article Affiliation country: Brazil Institution/Affiliation country: UFMA/BR