A new mechanism of action of dipyrone: blockade of the release of a nociceptive factor from macrophages
Braz. j. med. biol. res
;
21(3): 565-8, Mar. 1988. ilus
Article
in English
| LILACS
| ID: lil-60264
ABSTRACT
Rat macrophage monolayers pre-treated with endotoxin release into the incubating fluid a factor (MW >10,000) capable of inducing writhing in mice (MNF). This release was inhibited by dipyrone (3.5-35 microng/ml) but not by indomethacin (0.5-2 microng/ml). Writhing in mice induced by the factor is blocked by dipyrone (0.5-50 mg/kg) and indomethacin (0.5-2 mg/kg). These results indicate that in addition to the previously described direct blockade of hyperalgesia by dipyrone, this drug may also affect the release of MNF, wich induces in vivo nociception through the release of prostaglandin-like substances
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Index:
LILACS (Americas)
Main subject:
Nociceptors
/
Dipyrone
/
Indomethacin
/
Macrophages
Type of study:
Etiology study
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1988
Type:
Article
/
Congress and conference
/
Project document
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